A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation

The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chemically modified and detoxified variant, monophosphoryl lipid A (MPL). Although both molecules are active for human TLR4, they demonstrate a potency preference for mouse TLR4 based on data from transfe...

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Detalles Bibliográficos
Autores principales: Marshall, Jason D., Heeke, Darren S., Rao, Eileen, Maynard, Sean K., Hornigold, David, McCrae, Christopher, Fraser, Neil, Tovchigrechko, Andrey, Yu, Li, Williams, Nicola, King, Sarah, Cooper, Martin E., Hajjar, Adeline M., Woo, Jennifer C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063506/
https://www.ncbi.nlm.nih.gov/pubmed/27736941
http://dx.doi.org/10.1371/journal.pone.0164632

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