Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC

Tumor recurrence after surgical resection of NSCLC obstructs long-term disease-free survival in approximately 50% of cases. Our data suggest that combining circulating tumor cell enumeration (as single cells or clusters) in tumor-draining pulmonary vein and peripheral blood (assessed by CellSearch)...

Descripción completa

Detalles Bibliográficos
Autores principales: Crosbie, Phil A.J., Shah, Rajesh, Krysiak, Piotr, Zhou, Cong, Morris, Karen, Tugwood, Jonathan, Booton, Richard, Blackhall, Fiona, Dive, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063509/
https://www.ncbi.nlm.nih.gov/pubmed/27468936
http://dx.doi.org/10.1016/j.jtho.2016.06.017
Descripción
Sumario:Tumor recurrence after surgical resection of NSCLC obstructs long-term disease-free survival in approximately 50% of cases. Our data suggest that combining circulating tumor cell enumeration (as single cells or clusters) in tumor-draining pulmonary vein and peripheral blood (assessed by CellSearch) at the time of NSCLC surgery better identifies those patients at higher risk for lung cancer recurrence than does peripheral circulating tumor cell number alone.

Ejemplares similares