Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC

Tumor recurrence after surgical resection of NSCLC obstructs long-term disease-free survival in approximately 50% of cases. Our data suggest that combining circulating tumor cell enumeration (as single cells or clusters) in tumor-draining pulmonary vein and peripheral blood (assessed by CellSearch)...

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Autores principales: Crosbie, Phil A.J., Shah, Rajesh, Krysiak, Piotr, Zhou, Cong, Morris, Karen, Tugwood, Jonathan, Booton, Richard, Blackhall, Fiona, Dive, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063509/
https://www.ncbi.nlm.nih.gov/pubmed/27468936
http://dx.doi.org/10.1016/j.jtho.2016.06.017
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author Crosbie, Phil A.J.
Shah, Rajesh
Krysiak, Piotr
Zhou, Cong
Morris, Karen
Tugwood, Jonathan
Booton, Richard
Blackhall, Fiona
Dive, Caroline
author_facet Crosbie, Phil A.J.
Shah, Rajesh
Krysiak, Piotr
Zhou, Cong
Morris, Karen
Tugwood, Jonathan
Booton, Richard
Blackhall, Fiona
Dive, Caroline
author_sort Crosbie, Phil A.J.
collection PubMed
description Tumor recurrence after surgical resection of NSCLC obstructs long-term disease-free survival in approximately 50% of cases. Our data suggest that combining circulating tumor cell enumeration (as single cells or clusters) in tumor-draining pulmonary vein and peripheral blood (assessed by CellSearch) at the time of NSCLC surgery better identifies those patients at higher risk for lung cancer recurrence than does peripheral circulating tumor cell number alone.
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spelling pubmed-50635092016-10-18 Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC Crosbie, Phil A.J. Shah, Rajesh Krysiak, Piotr Zhou, Cong Morris, Karen Tugwood, Jonathan Booton, Richard Blackhall, Fiona Dive, Caroline J Thorac Oncol Brief Report Tumor recurrence after surgical resection of NSCLC obstructs long-term disease-free survival in approximately 50% of cases. Our data suggest that combining circulating tumor cell enumeration (as single cells or clusters) in tumor-draining pulmonary vein and peripheral blood (assessed by CellSearch) at the time of NSCLC surgery better identifies those patients at higher risk for lung cancer recurrence than does peripheral circulating tumor cell number alone. Elsevier 2016-10 /pmc/articles/PMC5063509/ /pubmed/27468936 http://dx.doi.org/10.1016/j.jtho.2016.06.017 Text en © 2016 International Association for the Study of Lung Cancer. Elsevier Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Brief Report
Crosbie, Phil A.J.
Shah, Rajesh
Krysiak, Piotr
Zhou, Cong
Morris, Karen
Tugwood, Jonathan
Booton, Richard
Blackhall, Fiona
Dive, Caroline
Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC
title Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC
title_full Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC
title_fullStr Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC
title_full_unstemmed Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC
title_short Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC
title_sort circulating tumor cells detected in the tumor-draining pulmonary vein are associated with disease recurrence after surgical resection of nsclc
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063509/
https://www.ncbi.nlm.nih.gov/pubmed/27468936
http://dx.doi.org/10.1016/j.jtho.2016.06.017
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