Unilateral Carotid Body Resection in Resistant Hypertension: A Safety and Feasibility Trial

Animal and human data indicate pathological afferent signaling emanating from the carotid body that drives sympathetically mediated elevations in blood pressure in conditions of hypertension. This first-in-man, proof-of-principle study tested the safety and feasibility of unilateral carotid body res...

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Detalles Bibliográficos
Autores principales: Narkiewicz, Krzysztof, Ratcliffe, Laura E.K., Hart, Emma C., Briant, Linford J.B., Chrostowska, Marzena, Wolf, Jacek, Szyndler, Anna, Hering, Dagmara, Abdala, Ana P., Manghat, Nathan, Burchell, Amy E., Durant, Claire, Lobo, Melvin D., Sobotka, Paul A., Patel, Nikunj K., Leiter, James C., Engelman, Zoar J., Nightingale, Angus K., Paton, Julian F.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
CLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063532/
https://www.ncbi.nlm.nih.gov/pubmed/27766316
http://dx.doi.org/10.1016/j.jacbts.2016.06.004
Descripción
Sumario:Animal and human data indicate pathological afferent signaling emanating from the carotid body that drives sympathetically mediated elevations in blood pressure in conditions of hypertension. This first-in-man, proof-of-principle study tested the safety and feasibility of unilateral carotid body resection in 15 patients with drug-resistant hypertension. The procedure proved to be safe and feasible. Overall, no change in blood pressure was found. However, 8 patients showed significant reductions in ambulatory blood pressure coinciding with decreases in sympathetic activity. The carotid body may be a novel target for treating an identifiable subpopulation of humans with hypertension.

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