Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus

The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity...

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Autores principales: Deng, Yong-Qiang, Zhang, Na-Na, Li, Chun-Feng, Tian, Min, Hao, Jia-Nan, Xie, Xu-Ping, Shi, Pei-Yong, Qin, Cheng-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063548/
https://www.ncbi.nlm.nih.gov/pubmed/27747251
http://dx.doi.org/10.1093/ofid/ofw175
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author Deng, Yong-Qiang
Zhang, Na-Na
Li, Chun-Feng
Tian, Min
Hao, Jia-Nan
Xie, Xu-Ping
Shi, Pei-Yong
Qin, Cheng-Feng
author_facet Deng, Yong-Qiang
Zhang, Na-Na
Li, Chun-Feng
Tian, Min
Hao, Jia-Nan
Xie, Xu-Ping
Shi, Pei-Yong
Qin, Cheng-Feng
author_sort Deng, Yong-Qiang
collection PubMed
description The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.
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spelling pubmed-50635482016-10-14 Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus Deng, Yong-Qiang Zhang, Na-Na Li, Chun-Feng Tian, Min Hao, Jia-Nan Xie, Xu-Ping Shi, Pei-Yong Qin, Cheng-Feng Open Forum Infect Dis Brief Reports The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery. Oxford University Press 2016-08-30 /pmc/articles/PMC5063548/ /pubmed/27747251 http://dx.doi.org/10.1093/ofid/ofw175 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Deng, Yong-Qiang
Zhang, Na-Na
Li, Chun-Feng
Tian, Min
Hao, Jia-Nan
Xie, Xu-Ping
Shi, Pei-Yong
Qin, Cheng-Feng
Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus
title Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus
title_full Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus
title_fullStr Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus
title_full_unstemmed Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus
title_short Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus
title_sort adenosine analog nitd008 is a potent inhibitor of zika virus
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063548/
https://www.ncbi.nlm.nih.gov/pubmed/27747251
http://dx.doi.org/10.1093/ofid/ofw175
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