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ESC-Derived BDNF-Overexpressing Neural Progenitors Differentially Promote Recovery in Huntington's Disease Models by Enhanced Striatal Differentiation

Huntington's disease (HD) is characterized by fatal motoric failures induced by loss of striatal medium spiny neurons. Neuronal cell death has been linked to impaired expression and axonal transport of the neurotrophin BDNF (brain-derived neurotrophic factor). By transplanting embryonic stem ce...

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Detalles Bibliográficos
Autores principales:	Zimmermann, Tina, Remmers, Floortje, Lutz, Beat, Leschik, Julia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063570/ https://www.ncbi.nlm.nih.gov/pubmed/27693427 http://dx.doi.org/10.1016/j.stemcr.2016.08.018

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