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Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation

Down syndrome (DS) is the leading genetic cause of mental retardation and is caused by a third copy of human chromosome 21. The different pathologies of DS involve many tissues with a distinct array of neural phenotypes. Here we characterize embryonic stem cell lines with DS (DS-ESCs), and focus on...

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Detalles Bibliográficos
Autores principales:	Halevy, Tomer, Biancotti, Juan-Carlos, Yanuka, Ofra, Golan-Lev, Tamar, Benvenisty, Nissim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Resource
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063584/ https://www.ncbi.nlm.nih.gov/pubmed/27618722 http://dx.doi.org/10.1016/j.stemcr.2016.08.003

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