Systemic administration of an HIV 1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization

We investigated the mucosal distribution and neutralization potency of rhesus recombinant versions of the HIV-specific, broadly neutralizing antibody b12 (RhB12) following intravenous administration to lactating rhesus monkeys. IgG and dimeric IgA (dIgA) administration resulted in high plasma concen...

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Detalles Bibliográficos
Autores principales: Fouda, Genevieve G., Eudailey, Joshua, Kunz, Erika L., Amos, Joshua D., Liebl, Brooke E., Himes, Jonathan, Boakye-Agyeman, Felix, Beck, Krista, Michaels, Anthony J., Cohen-Wolkowiez, Michael, Haynes, Barton F., Reimann, Keith A., Permar, Sallie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063654/
https://www.ncbi.nlm.nih.gov/pubmed/27072605
http://dx.doi.org/10.1038/mi.2016.32

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