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Biokinetic datasets of PEI F25-LMW complexed and non-complexed (32)P-siRNA within different lung compartments

Biokinetics data of lung-administered PEI F25-LMW/siRNA polyplexes within different lung compartments are presented. Thereby, at three different timepoints (1 h, 3 h, 8 h), the data was determined by calculations to the (32)P-radioactivity in the whole mouse body. Additionally, data was optimized to...

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Detalles Bibliográficos
Autores principales: Lipka, Jens, Semmler-Behnke, Manuela, Wenk, Alexander, Burkhardt, Jana, Aigner, Achim, Kreyling, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063804/
https://www.ncbi.nlm.nih.gov/pubmed/27761500
http://dx.doi.org/10.1016/j.dib.2016.03.092
Descripción
Sumario:Biokinetics data of lung-administered PEI F25-LMW/siRNA polyplexes within different lung compartments are presented. Thereby, at three different timepoints (1 h, 3 h, 8 h), the data was determined by calculations to the (32)P-radioactivity in the whole mouse body. Additionally, data was optimized to the available PEI F25-LMW/siRNA polyplexes in the target organ and therefore normalized to the sum of all lung compartments. Methods, other biokinetics data and the discussion of the results are published in “Biokinetic studies of non-complexed siRNA versus nano-sized PEI F25-LMW/siRNA polyplexes following intratracheal instillation into mice” (Lipka et al., 2016 [1]).