Genotypic and phenotypic heterogeneity in Streptococcus mutans isolated from diabetic patients in Rome, Italy

Our study focuses on the antimicrobial susceptibility, genotypic and phenotypic heterogeneity, and serotype classification of the Streptococcus mutans isolated from type II diabetic patients (n = 25; age 42–68). Eighty-two percent of isolates were classified as serotype c. No serotype k was present....

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Autores principales: De, Arpan, Pasquantonio, Guido, Cerroni, Loredana, Petrelli, Dezemona, Lauro, Davide, Longhi, Marta, Vitali, Luca A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063833/
https://www.ncbi.nlm.nih.gov/pubmed/27795936
http://dx.doi.org/10.1186/s40064-016-3470-0
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author De, Arpan
Pasquantonio, Guido
Cerroni, Loredana
Petrelli, Dezemona
Lauro, Davide
Longhi, Marta
Vitali, Luca A.
author_facet De, Arpan
Pasquantonio, Guido
Cerroni, Loredana
Petrelli, Dezemona
Lauro, Davide
Longhi, Marta
Vitali, Luca A.
author_sort De, Arpan
collection PubMed
description Our study focuses on the antimicrobial susceptibility, genotypic and phenotypic heterogeneity, and serotype classification of the Streptococcus mutans isolated from type II diabetic patients (n = 25; age 42–68). Eighty-two percent of isolates were classified as serotype c. No serotype k was present. Macrorestriction analysis of genomic DNA of the isolates exhibited a clonal diversity that paralleled the phenotypic heterogeneity, which was also assessed in terms of biofilm forming ability. Isolates were susceptible to all the classes of antibiotics. In conclusion a great heterogeneity and no antimicrobial resistance were apparent in the considered S. mutans strains from diabetic patients.
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spelling pubmed-50638332016-10-28 Genotypic and phenotypic heterogeneity in Streptococcus mutans isolated from diabetic patients in Rome, Italy De, Arpan Pasquantonio, Guido Cerroni, Loredana Petrelli, Dezemona Lauro, Davide Longhi, Marta Vitali, Luca A. Springerplus Research Our study focuses on the antimicrobial susceptibility, genotypic and phenotypic heterogeneity, and serotype classification of the Streptococcus mutans isolated from type II diabetic patients (n = 25; age 42–68). Eighty-two percent of isolates were classified as serotype c. No serotype k was present. Macrorestriction analysis of genomic DNA of the isolates exhibited a clonal diversity that paralleled the phenotypic heterogeneity, which was also assessed in terms of biofilm forming ability. Isolates were susceptible to all the classes of antibiotics. In conclusion a great heterogeneity and no antimicrobial resistance were apparent in the considered S. mutans strains from diabetic patients. Springer International Publishing 2016-10-13 /pmc/articles/PMC5063833/ /pubmed/27795936 http://dx.doi.org/10.1186/s40064-016-3470-0 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
De, Arpan
Pasquantonio, Guido
Cerroni, Loredana
Petrelli, Dezemona
Lauro, Davide
Longhi, Marta
Vitali, Luca A.
Genotypic and phenotypic heterogeneity in Streptococcus mutans isolated from diabetic patients in Rome, Italy
title Genotypic and phenotypic heterogeneity in Streptococcus mutans isolated from diabetic patients in Rome, Italy
title_full Genotypic and phenotypic heterogeneity in Streptococcus mutans isolated from diabetic patients in Rome, Italy
title_fullStr Genotypic and phenotypic heterogeneity in Streptococcus mutans isolated from diabetic patients in Rome, Italy
title_full_unstemmed Genotypic and phenotypic heterogeneity in Streptococcus mutans isolated from diabetic patients in Rome, Italy
title_short Genotypic and phenotypic heterogeneity in Streptococcus mutans isolated from diabetic patients in Rome, Italy
title_sort genotypic and phenotypic heterogeneity in streptococcus mutans isolated from diabetic patients in rome, italy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063833/
https://www.ncbi.nlm.nih.gov/pubmed/27795936
http://dx.doi.org/10.1186/s40064-016-3470-0
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