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Do Dopaminergic Impairments Underlie Physical Inactivity in People with Obesity?
Obesity is associated with physical inactivity, which exacerbates the negative health consequences of obesity. Despite a wide consensus that people with obesity should exercise more, there are few effective methods for increasing physical activity in people with obesity. This lack is reflected in ou...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063846/ https://www.ncbi.nlm.nih.gov/pubmed/27790107 http://dx.doi.org/10.3389/fnhum.2016.00514 |
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author | Kravitz, Alexxai V. O'Neal, Timothy J. Friend, Danielle M. |
author_facet | Kravitz, Alexxai V. O'Neal, Timothy J. Friend, Danielle M. |
author_sort | Kravitz, Alexxai V. |
collection | PubMed |
description | Obesity is associated with physical inactivity, which exacerbates the negative health consequences of obesity. Despite a wide consensus that people with obesity should exercise more, there are few effective methods for increasing physical activity in people with obesity. This lack is reflected in our limited understanding of the cellular and molecular causes of physical inactivity in obesity. We hypothesize that impairments in dopamine signaling contribute to physical inactivity in people with obesity, as in classic movement disorders such as Parkinson's disease. Here, we review two lines of evidence supporting this hypothesis: (1) chronic exposure to obesogenic diets has been linked to impairments in dopamine synthesis, release, and receptor function, particularly in the striatum, and (2) striatal dopamine is necessary for the proper control of movement. Identifying the biological determinants of physical inactivity may lead to more effective strategies for increasing physical activity in people with obesity, as well as improve our understanding of why it is difficult for people with obesity to alter their levels of physical activity. |
format | Online Article Text |
id | pubmed-5063846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50638462016-10-27 Do Dopaminergic Impairments Underlie Physical Inactivity in People with Obesity? Kravitz, Alexxai V. O'Neal, Timothy J. Friend, Danielle M. Front Hum Neurosci Neuroscience Obesity is associated with physical inactivity, which exacerbates the negative health consequences of obesity. Despite a wide consensus that people with obesity should exercise more, there are few effective methods for increasing physical activity in people with obesity. This lack is reflected in our limited understanding of the cellular and molecular causes of physical inactivity in obesity. We hypothesize that impairments in dopamine signaling contribute to physical inactivity in people with obesity, as in classic movement disorders such as Parkinson's disease. Here, we review two lines of evidence supporting this hypothesis: (1) chronic exposure to obesogenic diets has been linked to impairments in dopamine synthesis, release, and receptor function, particularly in the striatum, and (2) striatal dopamine is necessary for the proper control of movement. Identifying the biological determinants of physical inactivity may lead to more effective strategies for increasing physical activity in people with obesity, as well as improve our understanding of why it is difficult for people with obesity to alter their levels of physical activity. Frontiers Media S.A. 2016-10-14 /pmc/articles/PMC5063846/ /pubmed/27790107 http://dx.doi.org/10.3389/fnhum.2016.00514 Text en Copyright © 2016 Kravitz, O'Neal and Friend. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Kravitz, Alexxai V. O'Neal, Timothy J. Friend, Danielle M. Do Dopaminergic Impairments Underlie Physical Inactivity in People with Obesity? |
title | Do Dopaminergic Impairments Underlie Physical Inactivity in People with Obesity? |
title_full | Do Dopaminergic Impairments Underlie Physical Inactivity in People with Obesity? |
title_fullStr | Do Dopaminergic Impairments Underlie Physical Inactivity in People with Obesity? |
title_full_unstemmed | Do Dopaminergic Impairments Underlie Physical Inactivity in People with Obesity? |
title_short | Do Dopaminergic Impairments Underlie Physical Inactivity in People with Obesity? |
title_sort | do dopaminergic impairments underlie physical inactivity in people with obesity? |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063846/ https://www.ncbi.nlm.nih.gov/pubmed/27790107 http://dx.doi.org/10.3389/fnhum.2016.00514 |
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