Elevated alpha1-acid glycoprotein in gastric cancer patients inhibits the anticancer effects of paclitaxel, effects restored by co-administration of erythromycin

Paclitaxel (PTX) which easily elutes into ascites is widely used to treat gastric cancer patients with peritoneal carcinomatosis (PC), but clinical outcomes are suboptimal. Increased concentrations of α1-acid glycoprotein (AGP), an important drug-binding protein, have been reported in the plasma and...

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Detalles Bibliográficos
Autores principales: Ohbatake, Yoshinao, Fushida, Sachio, Tsukada, Tomoya, Kinoshita, Jun, Oyama, Katsunobu, Hayashi, Hironori, Miyashita, Tomoharu, Tajima, Hidehiro, Takamura, Hiroyuki, Ninomiya, Itasu, Yashiro, Masakazu, Hirakawa, Kousei, Ohta, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063896/
https://www.ncbi.nlm.nih.gov/pubmed/26359244
http://dx.doi.org/10.1007/s10238-015-0387-9

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