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Accumulation of CD5(+)CD19(+) B lymphocytes expressing PD-1 and PD-1L in hypertrophied pharyngeal tonsils

Programmed death-1 (PD-1) is one of the most important inhibitory co-receptors expressed predominantly on activated T and B lymphocytes whose expression could be sustained by permanent antigenic stimulation accompanying chronic or recurrent tonsillitis. The expression of PD-1 and PD-1L was analyzed...

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Detalles Bibliográficos
Autores principales: Wlasiuk, Paulina, Niedzielski, Artur, Skorka, Katarzyna, Karczmarczyk, Agnieszka, Zaleska, Joanna, Zajac, Malgorzata, Putowski, Maciej, Pac-Kozuchowska, Elzbieta, Giannopoulos, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063907/
https://www.ncbi.nlm.nih.gov/pubmed/26319791
http://dx.doi.org/10.1007/s10238-015-0385-y
Descripción
Sumario:Programmed death-1 (PD-1) is one of the most important inhibitory co-receptors expressed predominantly on activated T and B lymphocytes whose expression could be sustained by permanent antigenic stimulation accompanying chronic or recurrent tonsillitis. The expression of PD-1 and PD-1L was analyzed using flow cytometry on hypertrophied tonsils collected from 57 children. We observed high expression of PD-1 and PD-1L on certain lymphocytes subpopulations of hypertrophied tonsils; among T cells, the expression of PD-1 on protein level was higher on CD4(+) cells (70.3 %) than on CD8(+) cells (35 %). Interestingly, a limited expression of PD-1 was observed on CD19(+) B lymphocytes (6.5 %), while CD5(+)CD19(+) B cells overexpressed PD-1 (52.5 %). Moreover, the expression of PD-1L was also higher on CD5(+)CD19(+) B cells (16.5 %) than on CD19(+) B cells (3.5 %) and on CD4(+) T cells (20 %) than on CD8(+) T cells (10 %). PD-1 and PD-1L expressions correlated only on CD5(+)CD19(+) cells. In conclusion, high expression of PD-1 and PD-1L on T and B cells could represent hallmark of immune system adaptation to chronic antigenic exposition in patients with tonsillitis.