Synthesis, characterization, and antioxidant activity of Zn(2+) and Cu(2+) coordinated polyhydroxychalcone complexes

ABSTRACT: Four new metal complexes [Cu(ISO)(2)], [Cu(BUT)(2)] and [Zn(ISO)(2)], [Zn(BUT)(2)] of the polyhydroxychalcones (isoliquiritigenin and butein) are synthesized, structurally characterized and their antioxidant activity is investigated. The formation of the complexes [Cu(ISO)(2)] and [Zn(ISO)...

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Autores principales: Sulpizio, Chiara, Müller, Simon T. R., Zhang, Qi, Brecker, Lothar, Rompel, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063914/
https://www.ncbi.nlm.nih.gov/pubmed/27795583
http://dx.doi.org/10.1007/s00706-016-1822-7
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author Sulpizio, Chiara
Müller, Simon T. R.
Zhang, Qi
Brecker, Lothar
Rompel, Annette
author_facet Sulpizio, Chiara
Müller, Simon T. R.
Zhang, Qi
Brecker, Lothar
Rompel, Annette
author_sort Sulpizio, Chiara
collection PubMed
description ABSTRACT: Four new metal complexes [Cu(ISO)(2)], [Cu(BUT)(2)] and [Zn(ISO)(2)], [Zn(BUT)(2)] of the polyhydroxychalcones (isoliquiritigenin and butein) are synthesized, structurally characterized and their antioxidant activity is investigated. The formation of the complexes [Cu(ISO)(2)] and [Zn(ISO)(2)] is followed by Job’s plot using NMR titration. The resulting compounds are characterized by mass spectrometry, IR spectroscopy, and elemental analysis. Studies on the radical scavenging activity are performed using DPPH as substrate. The results showed that the antioxidant activities of isoliquiritigenin and butein are enhanced after binding to copper or zinc. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00706-016-1822-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-50639142016-10-28 Synthesis, characterization, and antioxidant activity of Zn(2+) and Cu(2+) coordinated polyhydroxychalcone complexes Sulpizio, Chiara Müller, Simon T. R. Zhang, Qi Brecker, Lothar Rompel, Annette Monatsh Chem Original Paper ABSTRACT: Four new metal complexes [Cu(ISO)(2)], [Cu(BUT)(2)] and [Zn(ISO)(2)], [Zn(BUT)(2)] of the polyhydroxychalcones (isoliquiritigenin and butein) are synthesized, structurally characterized and their antioxidant activity is investigated. The formation of the complexes [Cu(ISO)(2)] and [Zn(ISO)(2)] is followed by Job’s plot using NMR titration. The resulting compounds are characterized by mass spectrometry, IR spectroscopy, and elemental analysis. Studies on the radical scavenging activity are performed using DPPH as substrate. The results showed that the antioxidant activities of isoliquiritigenin and butein are enhanced after binding to copper or zinc. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00706-016-1822-7) contains supplementary material, which is available to authorized users. Springer Vienna 2016-08-29 2016 /pmc/articles/PMC5063914/ /pubmed/27795583 http://dx.doi.org/10.1007/s00706-016-1822-7 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Sulpizio, Chiara
Müller, Simon T. R.
Zhang, Qi
Brecker, Lothar
Rompel, Annette
Synthesis, characterization, and antioxidant activity of Zn(2+) and Cu(2+) coordinated polyhydroxychalcone complexes
title Synthesis, characterization, and antioxidant activity of Zn(2+) and Cu(2+) coordinated polyhydroxychalcone complexes
title_full Synthesis, characterization, and antioxidant activity of Zn(2+) and Cu(2+) coordinated polyhydroxychalcone complexes
title_fullStr Synthesis, characterization, and antioxidant activity of Zn(2+) and Cu(2+) coordinated polyhydroxychalcone complexes
title_full_unstemmed Synthesis, characterization, and antioxidant activity of Zn(2+) and Cu(2+) coordinated polyhydroxychalcone complexes
title_short Synthesis, characterization, and antioxidant activity of Zn(2+) and Cu(2+) coordinated polyhydroxychalcone complexes
title_sort synthesis, characterization, and antioxidant activity of zn(2+) and cu(2+) coordinated polyhydroxychalcone complexes
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063914/
https://www.ncbi.nlm.nih.gov/pubmed/27795583
http://dx.doi.org/10.1007/s00706-016-1822-7
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