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Propionibacterium acnes Susceptibility and Correlation with Hemolytic Phenotype
BACKGROUND: Many studies have noted an increase in the number of recognized cases of invasive infections due to Propionibacterium acnes, especially after shoulder replacement surgery. The increase in the number of recognized cases of P. acnes, a nonspore-forming, anaerobic, Gram-positive organism, a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063917/ https://www.ncbi.nlm.nih.gov/pubmed/27773990 http://dx.doi.org/10.4137/IDRT.S40539 |
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author | Wright, Travis E. Boyle, K. Keely Duquin, Thomas R. Crane, John K. |
author_facet | Wright, Travis E. Boyle, K. Keely Duquin, Thomas R. Crane, John K. |
author_sort | Wright, Travis E. |
collection | PubMed |
description | BACKGROUND: Many studies have noted an increase in the number of recognized cases of invasive infections due to Propionibacterium acnes, especially after shoulder replacement surgery. The increase in the number of recognized cases of P. acnes, a nonspore-forming, anaerobic, Gram-positive organism, appears due to both an increase in the number of shoulder operations being performed and more specimens being sent for anaerobic cultures. Nevertheless, the optimal surgical and antibiotic management of P. acnes remains controversial. METHODS: We tested the susceptibility of 106 P. acnes strains from sterile body sites collected at the Erie County Medical Center between 2012 and 2015, using Etest gradient antibiotic strips. RESULTS: P. acnes is very susceptible to the penicillins and the first-generation cephalosporins. We noted an association between hemolytic phenotype on Brucella Blood Agar and clindamycin resistance. CONCLUSIONS: Antimicrobial susceptibility testing of P. acnes should no longer just be confined to the research laboratory but expanded and incorporated into routine microbiological evaluation of P. acnes. This would improve patient care as well as help clarify the relationship between hemolysis and clindamycin resistance. |
format | Online Article Text |
id | pubmed-5063917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-50639172016-10-21 Propionibacterium acnes Susceptibility and Correlation with Hemolytic Phenotype Wright, Travis E. Boyle, K. Keely Duquin, Thomas R. Crane, John K. Infect Dis (Auckl) Original Research BACKGROUND: Many studies have noted an increase in the number of recognized cases of invasive infections due to Propionibacterium acnes, especially after shoulder replacement surgery. The increase in the number of recognized cases of P. acnes, a nonspore-forming, anaerobic, Gram-positive organism, appears due to both an increase in the number of shoulder operations being performed and more specimens being sent for anaerobic cultures. Nevertheless, the optimal surgical and antibiotic management of P. acnes remains controversial. METHODS: We tested the susceptibility of 106 P. acnes strains from sterile body sites collected at the Erie County Medical Center between 2012 and 2015, using Etest gradient antibiotic strips. RESULTS: P. acnes is very susceptible to the penicillins and the first-generation cephalosporins. We noted an association between hemolytic phenotype on Brucella Blood Agar and clindamycin resistance. CONCLUSIONS: Antimicrobial susceptibility testing of P. acnes should no longer just be confined to the research laboratory but expanded and incorporated into routine microbiological evaluation of P. acnes. This would improve patient care as well as help clarify the relationship between hemolysis and clindamycin resistance. Libertas Academica 2016-10-09 /pmc/articles/PMC5063917/ /pubmed/27773990 http://dx.doi.org/10.4137/IDRT.S40539 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Original Research Wright, Travis E. Boyle, K. Keely Duquin, Thomas R. Crane, John K. Propionibacterium acnes Susceptibility and Correlation with Hemolytic Phenotype |
title | Propionibacterium acnes Susceptibility and Correlation with Hemolytic Phenotype |
title_full | Propionibacterium acnes Susceptibility and Correlation with Hemolytic Phenotype |
title_fullStr | Propionibacterium acnes Susceptibility and Correlation with Hemolytic Phenotype |
title_full_unstemmed | Propionibacterium acnes Susceptibility and Correlation with Hemolytic Phenotype |
title_short | Propionibacterium acnes Susceptibility and Correlation with Hemolytic Phenotype |
title_sort | propionibacterium acnes susceptibility and correlation with hemolytic phenotype |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063917/ https://www.ncbi.nlm.nih.gov/pubmed/27773990 http://dx.doi.org/10.4137/IDRT.S40539 |
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