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Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance?

Antibiotic resistance has been emerged as a major global health problem. In particular, gram-negative species pose a significant clinical challenge as bacteria develop or acquire more resistance mechanisms. Often, these bacteria possess multiple resistance mechanisms, thus nullifying most of the maj...

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Detalles Bibliográficos
Autor principal: Tillotson, Glenn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063921/
https://www.ncbi.nlm.nih.gov/pubmed/27773991
http://dx.doi.org/10.4137/IDRT.S31567
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author Tillotson, Glenn S.
author_facet Tillotson, Glenn S.
author_sort Tillotson, Glenn S.
collection PubMed
description Antibiotic resistance has been emerged as a major global health problem. In particular, gram-negative species pose a significant clinical challenge as bacteria develop or acquire more resistance mechanisms. Often, these bacteria possess multiple resistance mechanisms, thus nullifying most of the major classes of drugs. Novel approaches to this issue are urgently required. However, the challenges of developing new agents are immense. Introducing novel agents is fraught with hurdles, thus adapting known antibiotic classes by altering their chemical structure could be a way forward. A chemical addition to existing antibiotics known as a siderophore could be a solution to the gram-negative resistance issue. Siderophore molecules rely on the bacterial innate need for iron ions and thus can utilize a Trojan Horse approach to gain access to the bacterial cell. The current approaches to using this potential method are reviewed.
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spelling pubmed-50639212016-10-21 Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance? Tillotson, Glenn S. Infect Dis (Auckl) Review Antibiotic resistance has been emerged as a major global health problem. In particular, gram-negative species pose a significant clinical challenge as bacteria develop or acquire more resistance mechanisms. Often, these bacteria possess multiple resistance mechanisms, thus nullifying most of the major classes of drugs. Novel approaches to this issue are urgently required. However, the challenges of developing new agents are immense. Introducing novel agents is fraught with hurdles, thus adapting known antibiotic classes by altering their chemical structure could be a way forward. A chemical addition to existing antibiotics known as a siderophore could be a solution to the gram-negative resistance issue. Siderophore molecules rely on the bacterial innate need for iron ions and thus can utilize a Trojan Horse approach to gain access to the bacterial cell. The current approaches to using this potential method are reviewed. Libertas Academica 2016-10-11 /pmc/articles/PMC5063921/ /pubmed/27773991 http://dx.doi.org/10.4137/IDRT.S31567 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Review
Tillotson, Glenn S.
Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance?
title Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance?
title_full Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance?
title_fullStr Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance?
title_full_unstemmed Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance?
title_short Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance?
title_sort trojan horse antibiotics—a novel way to circumvent gram-negative bacterial resistance?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063921/
https://www.ncbi.nlm.nih.gov/pubmed/27773991
http://dx.doi.org/10.4137/IDRT.S31567
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