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Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance?
Antibiotic resistance has been emerged as a major global health problem. In particular, gram-negative species pose a significant clinical challenge as bacteria develop or acquire more resistance mechanisms. Often, these bacteria possess multiple resistance mechanisms, thus nullifying most of the maj...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Libertas Academica
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063921/ https://www.ncbi.nlm.nih.gov/pubmed/27773991 http://dx.doi.org/10.4137/IDRT.S31567 |
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author | Tillotson, Glenn S. |
author_facet | Tillotson, Glenn S. |
author_sort | Tillotson, Glenn S. |
collection | PubMed |
description | Antibiotic resistance has been emerged as a major global health problem. In particular, gram-negative species pose a significant clinical challenge as bacteria develop or acquire more resistance mechanisms. Often, these bacteria possess multiple resistance mechanisms, thus nullifying most of the major classes of drugs. Novel approaches to this issue are urgently required. However, the challenges of developing new agents are immense. Introducing novel agents is fraught with hurdles, thus adapting known antibiotic classes by altering their chemical structure could be a way forward. A chemical addition to existing antibiotics known as a siderophore could be a solution to the gram-negative resistance issue. Siderophore molecules rely on the bacterial innate need for iron ions and thus can utilize a Trojan Horse approach to gain access to the bacterial cell. The current approaches to using this potential method are reviewed. |
format | Online Article Text |
id | pubmed-5063921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-50639212016-10-21 Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance? Tillotson, Glenn S. Infect Dis (Auckl) Review Antibiotic resistance has been emerged as a major global health problem. In particular, gram-negative species pose a significant clinical challenge as bacteria develop or acquire more resistance mechanisms. Often, these bacteria possess multiple resistance mechanisms, thus nullifying most of the major classes of drugs. Novel approaches to this issue are urgently required. However, the challenges of developing new agents are immense. Introducing novel agents is fraught with hurdles, thus adapting known antibiotic classes by altering their chemical structure could be a way forward. A chemical addition to existing antibiotics known as a siderophore could be a solution to the gram-negative resistance issue. Siderophore molecules rely on the bacterial innate need for iron ions and thus can utilize a Trojan Horse approach to gain access to the bacterial cell. The current approaches to using this potential method are reviewed. Libertas Academica 2016-10-11 /pmc/articles/PMC5063921/ /pubmed/27773991 http://dx.doi.org/10.4137/IDRT.S31567 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Review Tillotson, Glenn S. Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance? |
title | Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance? |
title_full | Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance? |
title_fullStr | Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance? |
title_full_unstemmed | Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance? |
title_short | Trojan Horse Antibiotics—A Novel Way to Circumvent Gram-Negative Bacterial Resistance? |
title_sort | trojan horse antibiotics—a novel way to circumvent gram-negative bacterial resistance? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063921/ https://www.ncbi.nlm.nih.gov/pubmed/27773991 http://dx.doi.org/10.4137/IDRT.S31567 |
work_keys_str_mv | AT tillotsonglenns trojanhorseantibioticsanovelwaytocircumventgramnegativebacterialresistance |