Calcium/calmodulin‐dependent kinase II and nitric oxide synthase 1‐dependent modulation of ryanodine receptors during β‐adrenergic stimulation is restricted to the dyadic cleft

KEY POINTS: The dyadic cleft, where coupled ryanodine receptors (RyRs) reside, is thought to serve as a microdomain for local signalling, as supported by distinct modulation of coupled RyRs dependent on Ca(2+)/calmodulin‐dependent kinase II (CaMKII) activation during high‐frequency stimulation. Symp...

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Detalles Bibliográficos
Autores principales: Dries, Eef, Santiago, Demetrio J., Johnson, Daniel M., Gilbert, Guillaume, Holemans, Patricia, Korte, Sanne M., Roderick, H. Llewelyn, Sipido, Karin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Cardiovascular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063942/
https://www.ncbi.nlm.nih.gov/pubmed/27121757
http://dx.doi.org/10.1113/JP271965

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