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EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling

Ethylene gas is essential for many developmental processes and stress responses in plants. EIN2 plays a key role in ethylene signalling but its function remains enigmatic. Here, we show that ethylene specifically elevates acetylation of histone H3K14 and the non-canonical acetylation of H3K23 in eti...

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Autores principales: Zhang, Fan, Qi, Bin, Wang, Likai, Zhao, Bo, Rode, Siddharth, Riggan, Nathaniel D., Ecker, Joseph R., Qiao, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063967/
https://www.ncbi.nlm.nih.gov/pubmed/27694846
http://dx.doi.org/10.1038/ncomms13018
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author Zhang, Fan
Qi, Bin
Wang, Likai
Zhao, Bo
Rode, Siddharth
Riggan, Nathaniel D.
Ecker, Joseph R.
Qiao, Hong
author_facet Zhang, Fan
Qi, Bin
Wang, Likai
Zhao, Bo
Rode, Siddharth
Riggan, Nathaniel D.
Ecker, Joseph R.
Qiao, Hong
author_sort Zhang, Fan
collection PubMed
description Ethylene gas is essential for many developmental processes and stress responses in plants. EIN2 plays a key role in ethylene signalling but its function remains enigmatic. Here, we show that ethylene specifically elevates acetylation of histone H3K14 and the non-canonical acetylation of H3K23 in etiolated seedlings. The up-regulation of these two histone marks positively correlates with ethylene-regulated transcription activation, and the elevation requires EIN2. Both EIN2 and EIN3 interact with a SANT domain protein named EIN2 nuclear associated protein 1 (ENAP1), overexpression of which results in elevation of histone acetylation and enhanced ethylene-inducible gene expression in an EIN2-dependent manner. On the basis of these findings we propose a model where, in the presence of ethylene, the EIN2 C terminus contributes to downstream signalling via the elevation of acetylation at H3K14 and H3K23. ENAP1 may potentially mediate ethylene-induced histone acetylation via its interactions with EIN2 C terminus.
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spelling pubmed-50639672016-10-26 EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling Zhang, Fan Qi, Bin Wang, Likai Zhao, Bo Rode, Siddharth Riggan, Nathaniel D. Ecker, Joseph R. Qiao, Hong Nat Commun Article Ethylene gas is essential for many developmental processes and stress responses in plants. EIN2 plays a key role in ethylene signalling but its function remains enigmatic. Here, we show that ethylene specifically elevates acetylation of histone H3K14 and the non-canonical acetylation of H3K23 in etiolated seedlings. The up-regulation of these two histone marks positively correlates with ethylene-regulated transcription activation, and the elevation requires EIN2. Both EIN2 and EIN3 interact with a SANT domain protein named EIN2 nuclear associated protein 1 (ENAP1), overexpression of which results in elevation of histone acetylation and enhanced ethylene-inducible gene expression in an EIN2-dependent manner. On the basis of these findings we propose a model where, in the presence of ethylene, the EIN2 C terminus contributes to downstream signalling via the elevation of acetylation at H3K14 and H3K23. ENAP1 may potentially mediate ethylene-induced histone acetylation via its interactions with EIN2 C terminus. Nature Publishing Group 2016-10-03 /pmc/articles/PMC5063967/ /pubmed/27694846 http://dx.doi.org/10.1038/ncomms13018 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Fan
Qi, Bin
Wang, Likai
Zhao, Bo
Rode, Siddharth
Riggan, Nathaniel D.
Ecker, Joseph R.
Qiao, Hong
EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling
title EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling
title_full EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling
title_fullStr EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling
title_full_unstemmed EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling
title_short EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling
title_sort ein2-dependent regulation of acetylation of histone h3k14 and non-canonical histone h3k23 in ethylene signalling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063967/
https://www.ncbi.nlm.nih.gov/pubmed/27694846
http://dx.doi.org/10.1038/ncomms13018
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