Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children With Tuberculosis: Bread Crumb Trails in Random Forests

Background. The role of drug concentrations in clinical outcomes in children with tuberculosis is unclear. Target concentrations for dose optimization are unknown. Methods. Plasma drug concentrations measured in Indian children with tuberculosis were modeled using compartmental pharmacokinetic analy...

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Detalles Bibliográficos
Autores principales: Swaminathan, Soumya, Pasipanodya, Jotam G., Ramachandran, Geetha, Hemanth Kumar, A. K., Srivastava, Shashikant, Deshpande, Devyani, Nuermberger, Eric, Gumbo, Tawanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
A Development Paradigm for Novel Combination Regimens for Multidrug-Resistant and Drug-Susceptible Tuberculosis in Children: Flame for Work and Play
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064152/
https://www.ncbi.nlm.nih.gov/pubmed/27742636
http://dx.doi.org/10.1093/cid/ciw471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064152/
https://www.ncbi.nlm.nih.gov/pubmed/27742636
http://dx.doi.org/10.1093/cid/ciw471

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