A Facile, Improved Synthesis of Sildenafil and Its Analogues

This paper describes the facile synthesis of sildenafil citrate (1) and its related compounds through an improved chlorosulfonation reaction using chlorosulfonic acid and thionyl chloride. This synthesis results in pure sildenafil with high yield. The structures of the compounds were determined with...

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Detalles Bibliográficos
Autores principales: Raghava Reddy, Ambati. V., Srinivas, Garaga, Takshinamoorthy, Chandiran, Gupta Peruri, Badarinadh, Naidu, Andra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064236/
https://www.ncbi.nlm.nih.gov/pubmed/28117311
http://dx.doi.org/10.3390/scipharm84030447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064236/
https://www.ncbi.nlm.nih.gov/pubmed/28117311
http://dx.doi.org/10.3390/scipharm84030447

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