Cargando…

A Facile, Improved Synthesis of Sildenafil and Its Analogues

This paper describes the facile synthesis of sildenafil citrate (1) and its related compounds through an improved chlorosulfonation reaction using chlorosulfonic acid and thionyl chloride. This synthesis results in pure sildenafil with high yield. The structures of the compounds were determined with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raghava Reddy, Ambati. V., Srinivas, Garaga, Takshinamoorthy, Chandiran, Gupta Peruri, Badarinadh, Naidu, Andra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064236/ https://www.ncbi.nlm.nih.gov/pubmed/28117311 http://dx.doi.org/10.3390/scipharm84030447

Ejemplares similares

Synthesis and Characterization of Impurities in the Production Process of Lopinavir
por: Raghava Reddy, Ambati V., et al.
Publicado: (2015)

Synthesis and Characterization of Compounds Related to Lisinopril
por: Raghava Reddy, Ambati V., et al.
Publicado: (2016)

Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug
por: Garaga, Srinivas, et al.
Publicado: (2013)

Facile and Sustainable Synthesis of Commendamide and its Analogues
por: Villano, Rosaria, et al.
Publicado: (2022)

An Alternative Approach to Isoganciclovir: A Prominent Impurity in the Antiviral Drug Ganciclovir
por: Sundaram, Dhanraj T. S. S., et al.
Publicado: (2015)

Identification, Isolation, and Characterization of a New Degradation Impurity in Nafcillin Sodium
por: Vundavilli, Jagadeesh Kumar, et al.
Publicado: (2015)

Isolation and identification of an isomeric sildenafil analogue as an adulterant in an instant coffee premix
por: Mohd Yusop, Ahmad Yusri, et al.
Publicado: (2020)

NaHSO(4)-SiO(2) as an efficient and chemoselective catalyst, for the synthesis of acylal from aldehydes under, solvent-free conditions
por: Kannasani, Ravi Kumar, et al.
Publicado: (2012)

An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues
por: Ghozlan, Said A S, et al.
Publicado: (2007)

Why sildenafil and sildenafil citrate monohydrate crystals are not stable?
por: Sawatdee, Somchai, et al.
Publicado: (2015)

A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin
por: Carbone, Anna, et al.
Publicado: (2013)

Persistent Pulmonary Hypertension of the Newborn: The Efficacy Comparison of Vasodilators Sildenafil Plus Bosentan Versus Sildenafil Plus Beraprost at a Tertiary Childcare Health Facility
por: Adnan, Mudasser, et al.
Publicado: (2021)

An improved synthesis of adefovir and related analogues
por: Jones, David J, et al.
Publicado: (2019)

Does sildenafil improve ventilatory function in asthmatic subjects?
por: Aljanabi, Mukhallad, et al.
Publicado: (2017)

A novel and efficient one-pot strategy for the synthesis of 1,2,4-triazoles: access to synthesis of penipanoid A and its analogues
por: Reddy, A. Satyanarayana, et al.
Publicado: (2023)

Facile Synthesis of β-Tetracyano Vanadyl Porphyrin from Its Tetrabromo Analogue and Its Excellent Catalytic Activity for Bromination and Epoxidation Reactions
por: Maurya, Mannar R., et al.
Publicado: (2023)

SILDENAFIL (VIAGRA) AND THE HEART
por: Chamsi-Pasha, Hassan
Publicado: (2001)

Sildenafil in Infants and Children
por: Simonca, Larisa, et al.
Publicado: (2017)

Sildenafil and suicide in Sweden
por: Catalano, Ralph, et al.
Publicado: (2021)

Synthesis of compounds related to the anti-migraine drug eletriptan hydrobromide
por: Madasu, Suri Babu, et al.
Publicado: (2012)

Sulphonated graphene oxide catalyzed continuous flow synthesis of pyrazolo pyrimidinones, sildenafil and other PDE-5 inhibitors
por: Sthalam, Vinay Kumar, et al.
Publicado: (2021)

Facile synthesis of fluorescent hetero[8]circulene analogues with tunable solubilities and optical properties
por: Matsuo, Yusuke, et al.
Publicado: (2019)

Nonrevascularizable buttock claudication improved with Sildenafil: A case report
por: Omarjee, Loukman, et al.
Publicado: (2017)

Pharmacokinetic and Pharmacodynamic Comparison of Sildenafil‐Bosentan and Sildenafil‐Ambrisentan Combination Therapies for Pulmonary Hypertension
por: Hakamata, A, et al.
Publicado: (2016)

Efficient Synthesis and Antibacterial Evaluation of (±)-Yanglingmycin and Its Analogues
por: Dan, Wenjia, et al.
Publicado: (2016)

Synthesis and Glycosidase Inhibition of Broussonetine M and Its Analogues
por: Wu, Qing-Kun, et al.
Publicado: (2019)

Synthesis and Bioactivity Evaluation of Nepetaefolin F and Its Analogues
por: Mao, Xu-Dong, et al.
Publicado: (2023)

Correction: Sulphonated graphene oxide catalyzed continuous flow synthesis of pyrazolo pyrimidinones, sildenafil and other PDE-5 inhibitors
por: Sthalam, Vinay Kumar, et al.
Publicado: (2023)

Improved Synthesis of Analogues of Red Wine Pyranoanthocyanin Pigments
por: da Silva, Cassio Pacheco, et al.
Publicado: (2018)

Sildenafil in the treatment of pulmonary hypertension
por: Barnett, Christopher F, et al.
Publicado: (2006)

Utilization and Cost of Sildenafil in a Large Managed Care Organization With a Quantity Limit on Sildenafil
por: Cooke, Catherine E., et al.
Publicado: (2005)

Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues
por: Zhao, Meng, et al.
Publicado: (2020)

Efficacy, safety and tolerability of bosentan as an adjuvant to sildenafil and sildenafil alone in persistant pulmonary hypertension of newborn (PPHN)
por: Vijay Kumar, J.R., et al.
Publicado: (2021)

Sildenafil Citrate in Fetal Growth Restriction
por: Panda, Subrat, et al.
Publicado: (2014)

Is Sildenafil a Therapeutic Option for Noncompaction?
por: Finsterer, Josef, et al.
Publicado: (2014)

Sildenafil Induced Acute Interstitial Nephritis
por: Burkhart, Ryan, et al.
Publicado: (2015)

Sildenafil in pediatric pulmonary arterial hypertension
por: Dhariwal, AK, et al.
Publicado: (2015)

The hypertensive effect of sorafenib is abolished by sildenafil
por: Dabiré, Hubert, et al.
Publicado: (2020)

Hypothesis of COVID-19 Therapy with Sildenafil
por: Mario, Limodio, et al.
Publicado: (2020)

Sildenafil Recovers Burn-Induced Cardiomyopathy
por: Wen, Jake J., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5ouhb3l81v2p4nspvs96el0v3o