In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb

The present study aimed to investigate the role of several biologically active compounds from Fumaria schleicheri Soy.-Will. in anticonvulsant models. The flavonoid fraction, alkaloid fraction, individual alkaloid protopine, and polysaccharide-protein complex were isolated from the Fumaria schleiche...

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Autores principales: Prokopenko, Yuliya, Tsyvunin, Vadim, Shtrygol’, Sergey, Georgiyants, Victoriya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064245/
https://www.ncbi.nlm.nih.gov/pubmed/28117320
http://dx.doi.org/10.3390/scipharm84030547
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author Prokopenko, Yuliya
Tsyvunin, Vadim
Shtrygol’, Sergey
Georgiyants, Victoriya
author_facet Prokopenko, Yuliya
Tsyvunin, Vadim
Shtrygol’, Sergey
Georgiyants, Victoriya
author_sort Prokopenko, Yuliya
collection PubMed
description The present study aimed to investigate the role of several biologically active compounds from Fumaria schleicheri Soy.-Will. in anticonvulsant models. The flavonoid fraction, alkaloid fraction, individual alkaloid protopine, and polysaccharide-protein complex were isolated from the Fumaria schleicheri herb and studied along with Fumaria schleicheri dry extract in mice with pentylenetetrazole-induced seizures. According to empirical results, the expressed anticonvulsant effect of Fumaria schleicheri dry extract depends on the synergism of biologically active compounds in herbal medicine, although some individual substances (mostly protopine and the protein-polysaccharide fraction) have shown moderate anti-seizure activity.
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spelling pubmed-50642452016-10-27 In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb Prokopenko, Yuliya Tsyvunin, Vadim Shtrygol’, Sergey Georgiyants, Victoriya Sci Pharm Article The present study aimed to investigate the role of several biologically active compounds from Fumaria schleicheri Soy.-Will. in anticonvulsant models. The flavonoid fraction, alkaloid fraction, individual alkaloid protopine, and polysaccharide-protein complex were isolated from the Fumaria schleicheri herb and studied along with Fumaria schleicheri dry extract in mice with pentylenetetrazole-induced seizures. According to empirical results, the expressed anticonvulsant effect of Fumaria schleicheri dry extract depends on the synergism of biologically active compounds in herbal medicine, although some individual substances (mostly protopine and the protein-polysaccharide fraction) have shown moderate anti-seizure activity. MDPI 2015-12-06 2016 /pmc/articles/PMC5064245/ /pubmed/28117320 http://dx.doi.org/10.3390/scipharm84030547 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Prokopenko, Yuliya
Tsyvunin, Vadim
Shtrygol’, Sergey
Georgiyants, Victoriya
In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb
title In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb
title_full In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb
title_fullStr In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb
title_full_unstemmed In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb
title_short In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb
title_sort in vivo anticonvulsant activity of extracts and protopine from the fumaria schleicheri herb
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064245/
https://www.ncbi.nlm.nih.gov/pubmed/28117320
http://dx.doi.org/10.3390/scipharm84030547
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