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Allosteric communication pathways routed by Ca(2+)/Mg(2+) exchange in GCAP1 selectively switch target regulation modes
GCAP1 is a neuronal calcium sensor protein that regulates the phototransduction cascade in vertebrates by switching between activator and inhibitor of the target guanylate cyclase (GC) in a Ca(2+)-dependent manner. We carried out exhaustive molecular dynamics simulations of GCAP1 and determined the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064319/ https://www.ncbi.nlm.nih.gov/pubmed/27739433 http://dx.doi.org/10.1038/srep34277 |