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Evaluation of the human adaptation of influenza A/H7N9 virus in PB2 protein using human and swine respiratory tract explant cultures

Novel avian H7N9 virus emerged in China in 2013 resulting in a case fatality rate of around 39% and continues to pose zoonotic and pandemic risk. Amino acid substitutions in PB2 protein were shown to influence the pathogenicity and transmissibility of H7N9 following experimental infection of ferrets...

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Detalles Bibliográficos
Autores principales:	Chan, Louisa L. Y., Bui, Christine T. H., Mok, Chris K. P., Ng, Mandy M. T., Nicholls, John M., Peiris, J. S. Malik, Chan, Michael C. W., Chan, Renee W. Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064379/ https://www.ncbi.nlm.nih.gov/pubmed/27739468 http://dx.doi.org/10.1038/srep35401

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