CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis

Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted therapies available. This is, in part, due to...

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Detalles Bibliográficos
Autores principales: Naert, Thomas, Colpaert, Robin, Van Nieuwenhuysen, Tom, Dimitrakopoulou, Dionysia, Leoen, Jannick, Haustraete, Jurgen, Boel, Annekatrien, Steyaert, Wouter, Lepez, Trees, Deforce, Dieter, Willaert, Andy, Creytens, David, Vleminckx, Kris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064383/
https://www.ncbi.nlm.nih.gov/pubmed/27739525
http://dx.doi.org/10.1038/srep35264

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