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Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency
Common strategy of genome-wide association studies (GWAS) relying on large samples faces difficulties, which raise concerns that GWAS have exhausted their potential, particularly for complex traits. Here, we examine the efficiency of the traditional sample-size-centered strategy in GWAS of these tra...
Autores principales: | Kulminski, Alexander M., Loika, Yury, Culminskaya, Irina, Arbeev, Konstantin G., Ukraintseva, Svetlana V., Stallard, Eric, Yashin, Anatoliy I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064392/ https://www.ncbi.nlm.nih.gov/pubmed/27739495 http://dx.doi.org/10.1038/srep35390 |
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