Cargando…

A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells

Hutchinson-Gilford progeria syndrome (HGPS) is a rare fatal genetic disorder that causes systemic accelerated aging in children. Thanks to the pluripotency and self-renewal properties of induced pluripotent stem cells (iPSC), HGPS iPSC-based modeling opens up the possibility of access to different r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lo Cicero, Alessandra, Jaskowiak, Anne-Laure, Egesipe, Anne-Laure, Tournois, Johana, Brinon, Benjamin, Pitrez, Patricia R., Ferreira, Lino, de Sandre-Giovannoli, Annachiara, Levy, Nicolas, Nissan, Xavier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064407/ https://www.ncbi.nlm.nih.gov/pubmed/27739443 http://dx.doi.org/10.1038/srep34798

Ejemplares similares

Pathological modelling of pigmentation disorders associated with Hutchinson-Gilford Progeria Syndrome (HGPS) revealed an impaired melanogenesis pathway in iPS-derived melanocytes
por: Lo Cicero, Alessandra, et al.
Publicado: (2018)

Metformin decreases progerin expression and alleviates pathological defects of Hutchinson–Gilford progeria syndrome cells
por: Egesipe, Anne-Laure, et al.
Publicado: (2016)

Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells
por: Harhouri, Karim, et al.
Publicado: (2016)

Development of a SMCs model from HGPS-iPS and proofs of principle
por: Ferreira, Lino
Publicado: (2015)

MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients’ Cells
por: Harhouri, Karim, et al.
Publicado: (2022)

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation
por: Blondel, S, et al.
Publicado: (2016)

Accelerated atherosclerosis in HGPS
por: Hamczyk, Magda R., et al.
Publicado: (2018)

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
por: Pitrez, Patricia R., et al.
Publicado: (2020)

Pluripotent stem cells for pathological modelling of Hutchinson-Gilford Progeria Syndrome (HGPS) and drug discovery
por: Nissan, Xavier
Publicado: (2015)

MicroRNAs in hereditary and sporadic premature aging syndromes and other laminopathies
por: Frankel, Diane, et al.
Publicado: (2018)

Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson–Gilford progeria (HGPS)
por: Dreesen, Oliver
Publicado: (2020)

New therapeutic approaches to HGPS based on progerin inhibition
por: Pellegrini, Camilla
Publicado: (2015)

MG132‐induced progerin clearance is mediated by autophagy activation and splicing regulation
por: Harhouri, Karim, et al.
Publicado: (2017)

Identification of signaling pathways modifying human dopaminergic neuron development using a pluripotent stem cell-based high-throughput screening automated system: purinergic pathways as a proof-of-principle
por: Boissart, Claire, et al.
Publicado: (2023)

An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome
por: Harhouri, Karim, et al.
Publicado: (2018)

Progerin, an Aberrant Spliced Form of Lamin A, Is a Potential Therapeutic Target for HGPS
por: Kim, Bae-Hoon, et al.
Publicado: (2023)

Mesenchymal stem cells derived from patients with premature aging syndromes display hallmarks of physiological aging
por: Trani, Jean Philippe, et al.
Publicado: (2022)

An overview of new translational, clinical and therapeutic perspectives in laminopathies and other nuclear envelope-related diseases.
por: De Sandre-Giovannoli, Annachiara, et al.
Publicado: (2015)

Laminopathies’ Treatments Systematic Review: A Contribution Towards a ‘Treatabolome’
por: Atalaia, Antonio, et al.
Publicado: (2021)

Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways
por: Clements, Craig S., et al.
Publicado: (2019)

A Collodion Baby with Facial Dysmorphism, Limb Anomalies, Pachygyria and Genital Hypoplasia: A Mild Form of Neu-Laxova Syndrome or a New Entity?
por: Özcan, Deren, et al.
Publicado: (2013)

Contribution of Human Pluripotent Stem Cell-Based Models to Drug Discovery for Neurological Disorders
por: Benchoua, Alexandra, et al.
Publicado: (2021)

miR-376a-3p and miR-376b-3p overexpression in Hutchinson-Gilford progeria fibroblasts inhibits cell proliferation and induces premature senescence
por: Frankel, Diane, et al.
Publicado: (2022)

Altered modulation of lamin A/C‐HDAC2 interaction and p21 expression during oxidative stress response in HGPS
por: Mattioli, Elisabetta, et al.
Publicado: (2018)

Predicting transcription factor activities from combined analysis of microarray and ChIP data: a partial least squares approach
por: Boulesteix, Anne-Laure, et al.
Publicado: (2005)

Discordant Gene Expression Signatures and Related Phenotypic Differences in Lamin A- and A/C-Related Hutchinson-Gilford Progeria Syndrome (HGPS)
por: Plasilova, Martina, et al.
Publicado: (2011)

Identification of thiostrepton as a pharmacological approach to rescue misfolded alpha-sarcoglycan mutant proteins from degradation
por: Hoch, Lucile, et al.
Publicado: (2019)

Outcomes of 4 years of molecular genetic diagnosis on a panel of genes involved in premature aging syndromes, including laminopathies and related disorders
por: Grelet, Maude, et al.
Publicado: (2019)

RT-qPCR analyses on the osteogenic differentiation from human iPS cells: an investigation of reference genes
por: Okamura, Kensuke, et al.
Publicado: (2020)

The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion
por: Furmanova-Hollenstein, Polina, et al.
Publicado: (2013)

Exome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndrome
por: Bárcena, Clea, et al.
Publicado: (2014)

Beyond iPS!
Publicado: (2012)

IL‐6 counteracts the inhibitory effect of IL‐4 on osteogenic differentiation of human adipose stem cells
por: Bastidas‐Coral, Angela P., et al.
Publicado: (2019)

Aging in iPS cells
por: Miller, Justine, et al.
Publicado: (2014)

Counteracting beam loading effects in the PS booster
por: Rasmussen, N
Publicado: (1984)

Profiling the microRNA Expression in Human iPS and iPS-derived Retinal Pigment Epithelium
por: Wang, Heuy-Ching, et al.
Publicado: (2014)

Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to Light
por: Infante, Arantza, et al.
Publicado: (2021)

Understanding the mysteries of iPS cells
por: Cohen, Justin Brent, et al.
Publicado: (2009)

Evolving science enhanced with iPS
Publicado: (2007)

iPS Cells—The Triumphs and Tribulations
por: Sharma, Riddhi
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_osjufbej11v4g107d3ick9hfj4