FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice

FUS/TLS is an RNA/DNA-binding protein associated with neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Previously, we found that a prion-like domain in the N-terminus of FUS/TLS mediates co-aggregation between FUS/TLS and mutant huntingtin, th...

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Detalles Bibliográficos
Autores principales: Kino, Yoshihiro, Washizu, Chika, Kurosawa, Masaru, Yamada, Mizuki, Doi, Hiroshi, Takumi, Toru, Adachi, Hiroaki, Katsuno, Masahisa, Sobue, Gen, Hicks, Geoffrey G., Hattori, Nobutaka, Shimogori, Tomomi, Nukina, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064419/
https://www.ncbi.nlm.nih.gov/pubmed/27739513
http://dx.doi.org/10.1038/srep35236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064419/
https://www.ncbi.nlm.nih.gov/pubmed/27739513
http://dx.doi.org/10.1038/srep35236

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