Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

The antiviral activity of UV-4 was previously demonstrated against dengue virus serotype 2 (DENV2) in multiple mouse models. Herein, step-wise minimal effective dose and therapeutic window of efficacy studies of UV-4B (UV-4 hydrochloride salt) were conducted in an antibody-dependent enhancement (ADE...

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Detalles Bibliográficos
Autores principales: Warfield, Kelly L., Plummer, Emily M., Sayce, Andrew C., Alonzi, Dominic S., Tang, William, Tyrrell, Beatrice E., Hill, Michelle L., Caputo, Alessandro T., Killingbeck, Sarah S., Beatty, P. Robert, Harris, Eva, Iwaki, Ren, Kinami, Kyoko, Ide, Daisuke, Kiappes, J.L., Kato, Atsushi, Buck, Michael D., King, Kevin, Eddy, William, Khaliq, Mansoora, Sampath, Aruna, Treston, Anthony M., Dwek, Raymond A., Enterlein, Sven G., Miller, Joanna L., Zitzmann, Nicole, Ramstedt, Urban, Shresta, Sujan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064435/
https://www.ncbi.nlm.nih.gov/pubmed/26946111
http://dx.doi.org/10.1016/j.antiviral.2016.03.001

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