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Evaluation of a Scenario in Which Estimates of Bioequivalence Are Biased and a Proposed Solution: t(last) (Common)
In bioequivalence (BE) testing, it is the convention to identify t(last) separately for each concentration‐vs‐time profile. Within‐subject differences in t(last) between treatments can arise when assay sensitivity is reached during washout, causing profiles to fall below the limit of quantitation (L...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064724/ https://www.ncbi.nlm.nih.gov/pubmed/26479406 http://dx.doi.org/10.1002/jcph.663 |