In vitro impact of pegvisomant on growth hormone-secreting pituitary adenoma cells

Pegvisomant (PEG), an antagonist of growth hormone (GH)-receptor (GHR), normalizes insulin-like growth factor 1 (IGF1) oversecretion in most acromegalic patients unresponsive to somatostatin analogs (SSAs) and/or uncontrolled by transsphenoidal surgery. The residual GH-secreting tumor is therefore e...

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Detalles Bibliográficos
Autores principales: Cuny, Thomas, Zeiller, Caroline, Bidlingmaier, Martin, Défilles, Céline, Roche, Catherine, Blanchard, Marie-Pierre, Theodoropoulou, Marily, Graillon, Thomas, Pertuit, Morgane, Figarella-Branger, Dominique, Enjalbert, Alain, Brue, Thierry, Barlier, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064756/
https://www.ncbi.nlm.nih.gov/pubmed/27267119
http://dx.doi.org/10.1530/ERC-16-0140

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