Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol

Melanocortin receptor accessory protein 2 (MRAP2) is a transmembrane accessory protein predominantly expressed in the brain. Both global and brain-specific deletion of Mrap2 in mice results in severe obesity. Loss-of-function MRAP2 mutations have also been associated with obesity in humans. Although...

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Detalles Bibliográficos
Autores principales: Novoselova, T V, Larder, R, Rimmington, D, Lelliott, C, Wynn, E H, Gorrigan, R J, Tate, P H, Guasti, L, O’Rahilly, S, Clark, A J L, Logan, D W, Coll, A P, Chan, L F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064762/
https://www.ncbi.nlm.nih.gov/pubmed/27106110
http://dx.doi.org/10.1530/JOE-16-0057

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