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Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification
Primordial germ cell (PGC) development is characterized by global epigenetic remodeling, which resets genomic potential and establishes an epigenetic ground state. Here we recapitulate PGC specification in vitro from naive embryonic stem cells and characterize the early events of epigenetic reprogra...
Autores principales: | von Meyenn, Ferdinand, Berrens, Rebecca V., Andrews, Simon, Santos, Fátima, Collier, Amanda J., Krueger, Felix, Osorno, Rodrigo, Dean, Wendy, Rugg-Gunn, Peter J., Reik, Wolf |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064768/ https://www.ncbi.nlm.nih.gov/pubmed/27728778 http://dx.doi.org/10.1016/j.devcel.2016.09.015 |
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