Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification

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Primordial germ cell (PGC) development is characterized by global epigenetic remodeling, which resets genomic potential and establishes an epigenetic ground state. Here we recapitulate PGC specification in vitro from naive embryonic stem cells and characterize the early events of epigenetic reprogra...

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Detalles Bibliográficos
Autores principales: von Meyenn, Ferdinand, Berrens, Rebecca V., Andrews, Simon, Santos, Fátima, Collier, Amanda J., Krueger, Felix, Osorno, Rodrigo, Dean, Wendy, Rugg-Gunn, Peter J., Reik, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064768/
https://www.ncbi.nlm.nih.gov/pubmed/27728778
http://dx.doi.org/10.1016/j.devcel.2016.09.015
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