Cargando…
Elimination of Chronic Lymphocytic Leukemia Cells in Stromal Microenvironment by Targeting CPT with an Anti-Angina Drug Perhexiline
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western countries and is currently incurable due in part to difficulty in eliminating the leukemia cells protected by stromal microenvironment. Based on previous observations that CLL cells exhibit mitochondrial dysfunction...
Autores principales: | Liu, Pan-pan, Liu, Jinyun, Jiang, Wen-qi, Carew, Jennifer S., Ogasawara, Marcia A., Pelicano, Hélène, Croce, Carlo M., Estrov, Zeev, Xu, Rui-hua, Keating, Michael J., Huang, Peng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064824/ https://www.ncbi.nlm.nih.gov/pubmed/27065330 http://dx.doi.org/10.1038/onc.2016.103 |
Ejemplares similares
-
Effective elimination of chronic lymphocytic leukemia cells in the stromal microenvironment by a novel drug combination strategy using redox-mediated mechanisms
por: ZHANG, WAN, et al.
Publicado: (2015) -
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukemia
por: Zhang, Wan, et al.
Publicado: (2012) -
Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome
por: Yin, Xiaoke, et al.
Publicado: (2013) -
Targeting p53-deficient chronic lymphocytic leukemia cells in vitro and in vivo by ROS-mediated mechanism
por: Liu, Jinyun, et al.
Publicado: (2016) -
Stat3 Activates the Receptor Tyrosine Kinase Like Orphan Receptor-1 Gene in Chronic Lymphocytic Leukemia Cells
por: Li, Ping, et al.
Publicado: (2010)