Prognostic impact of KRAS, NRAS, BRAF, and PIK3CA mutations in primary colorectal carcinomas: a population-based study

BACKGROUND: Activation of oncogenes downstream the EGFR gene contributes to colorectal tumorigenesis and determines the sensitivity to anti-EGFR treatments. The aim of this study was to evaluate the prognostic value of KRAS, BRAF, NRAS and PIK3CA mutations in a large collection of CRC patients from...

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Detalles Bibliográficos
Autores principales: Palomba, Grazia, Doneddu, Valentina, Cossu, Antonio, Paliogiannis, Panagiotis, Manca, Antonella, Casula, Milena, Colombino, Maria, Lanzillo, Annamaria, Defraia, Efisio, Pazzola, Antonio, Sanna, Giovanni, Putzu, Carlo, Ortu, Salvatore, Scartozzi, Mario, Ionta, Maria Teresa, Baldino, Giovanni, Sarobba, Giuseppina, Capelli, Francesca, Sedda, Tito, Virdis, Luciano, Barca, Michela, Gramignano, Giulia, Budroni, Mario, Tanda, Francesco, Palmieri, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064898/
https://www.ncbi.nlm.nih.gov/pubmed/27737711
http://dx.doi.org/10.1186/s12967-016-1053-z

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