Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis

Isocitrate dehydrogenase 1 mutations drive human gliomagenesis, probably through neomorphic enzyme activity that produces D-2-hydroxyglutarate. To model this disease, we conditionally expressed Idh1(R132H) in the subventricular zone (SVZ) of the adult mouse brain. The mice developed hydrocephalus an...

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Detalles Bibliográficos
Autores principales: Bardella, Chiara, Al-Dalahmah, Osama, Krell, Daniel, Brazauskas, Pijus, Al-Qahtani, Khalid, Tomkova, Marketa, Adam, Julie, Serres, Sébastien, Lockstone, Helen, Freeman-Mills, Luke, Pfeffer, Inga, Sibson, Nicola, Goldin, Robert, Schuster-Böeckler, Benjamin, Pollard, Patrick J., Soga, Tomoyoshi, McCullagh, James S., Schofield, Christopher J., Mulholland, Paul, Ansorge, Olaf, Kriaucionis, Skirmantas, Ratcliffe, Peter J., Szele, Francis G., Tomlinson, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064912/
https://www.ncbi.nlm.nih.gov/pubmed/27693047
http://dx.doi.org/10.1016/j.ccell.2016.08.017

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