Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer

Most breast cancers are driven by a transcription factor called oestrogen receptor (ER). Understanding the mechanisms of ER activity in breast cancer has been a major research interest and recent genomic advances have revealed extraordinary insights into how ER mediates gene transcription and what o...

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Detalles Bibliográficos
Autor principal: Carroll, J S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065078/
https://www.ncbi.nlm.nih.gov/pubmed/26884552
http://dx.doi.org/10.1530/EJE-16-0124
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author Carroll, J S
author_facet Carroll, J S
author_sort Carroll, J S
collection PubMed
description Most breast cancers are driven by a transcription factor called oestrogen receptor (ER). Understanding the mechanisms of ER activity in breast cancer has been a major research interest and recent genomic advances have revealed extraordinary insights into how ER mediates gene transcription and what occurs during endocrine resistance. This review discusses our current understanding on ER activity, with an emphasis on several evolving, but important areas of ER biology.
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spelling pubmed-50650782016-10-17 Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer Carroll, J S Eur J Endocrinol Review Most breast cancers are driven by a transcription factor called oestrogen receptor (ER). Understanding the mechanisms of ER activity in breast cancer has been a major research interest and recent genomic advances have revealed extraordinary insights into how ER mediates gene transcription and what occurs during endocrine resistance. This review discusses our current understanding on ER activity, with an emphasis on several evolving, but important areas of ER biology. Bioscientifica Ltd 2016-07 2016-07 /pmc/articles/PMC5065078/ /pubmed/26884552 http://dx.doi.org/10.1530/EJE-16-0124 Text en © 2016 The authors http://creativecommons.org/licenses/by/3.0/deed.en_GB This work is licensed under a Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/deed.en_GB) .
spellingShingle Review
Carroll, J S
Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer
title Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer
title_full Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer
title_fullStr Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer
title_full_unstemmed Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer
title_short Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer
title_sort mechanisms of oestrogen receptor (er) gene regulation in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065078/
https://www.ncbi.nlm.nih.gov/pubmed/26884552
http://dx.doi.org/10.1530/EJE-16-0124
work_keys_str_mv AT carrolljs mechanismsofoestrogenreceptorergeneregulationinbreastcancer

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