Round Spermatid Injection Rescues Female Lethality of a Paternally Inherited Xist Deletion in Mouse

In mouse female preimplantation embryos, the paternal X chromosome (Xp) is silenced by imprinted X chromosome inactivation (iXCI). This requires production of the noncoding Xist RNA in cis, from the Xp. The Xist locus on the maternally inherited X chromosome (Xm) is refractory to activation due to t...

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Detalles Bibliográficos
Autores principales: Federici, Federica, Magaraki, Aristea, Wassenaar, Evelyne, van Veen-Buurman, Catherina J. H., van de Werken, Christine, Baart, Esther B, Laven, Joop S. E., Grootegoed, J Anton, Gribnau, Joost, Baarends, Willy M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065126/
https://www.ncbi.nlm.nih.gov/pubmed/27716834
http://dx.doi.org/10.1371/journal.pgen.1006358

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