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Primary breast diffuse large B-cell lymphoma in the era of rituximab

BACKGROUND AND OBJECTIVE: The aim of this study was to summarize the clinical characteristics and evaluate the management approaches of primary breast diffuse large B-cell lymphoma (DLBCL) in the era of rituximab. PATIENTS AND METHODS: A total of 24 female patients with newly diagnosed primary breas...

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Detalles Bibliográficos
Autores principales: Zhang, Na, Cao, Caineng, Zhu, Yuan, Liu, Peng, Liu, Luying, Lu, Ke, Luo, Jialin, Zhou, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065257/
https://www.ncbi.nlm.nih.gov/pubmed/27785056
http://dx.doi.org/10.2147/OTT.S108839
Descripción
Sumario:BACKGROUND AND OBJECTIVE: The aim of this study was to summarize the clinical characteristics and evaluate the management approaches of primary breast diffuse large B-cell lymphoma (DLBCL) in the era of rituximab. PATIENTS AND METHODS: A total of 24 female patients with newly diagnosed primary breast DLBCL treated between April 2006 and May 2013 were analyzed retrospectively. Ten patients (41.7%) received rituximab. RESULTS: For the whole group, the median age was 50 years (range 24–69 years). All patients had the disease detected with a palpable mass. The estimated 5-year overall survival and progression-free survival (PFS) rates of all the patients were 78.9% and 79.2%, respectively. A nonstatistically significant increase in PFS and overall survival was observed when rituximab was administered (5-year PFS: 90% vs 71.4%, P=0.285; 5-year overall survival: 90% vs 71.4%, P=0.239). CONCLUSION: Primary breast DLBCL appears to be a rare disease. Adding rituximab might improve survival in patients with primary breast DLBCL. Further prospective studies are needed to evaluate the role of rituximab for primary breast DLBCL.