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Impaired vascular function in sepsis-surviving rats mediated by oxidative stress and Rho-Kinase pathway

We investigated long-lasting changes in endothelial and vascular function in adult rat survivors of severe sepsis induced by cecal ligation and puncture (CLP) model. For this, male Wistar rats (200–350 g) had their cecum punctured once (non-transfixing hole) with a 14-gauge needle. Performed in this...

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Detalles Bibliográficos
Autores principales: de Souza, Priscila, Guarido, Karla Lorena, Scheschowitsch, Karin, da Silva, Luísa Mota, Werner, Maria Fernanda, Assreuy, Jamil, da Silva-Santos, José Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065648/
https://www.ncbi.nlm.nih.gov/pubmed/27744119
http://dx.doi.org/10.1016/j.redox.2016.09.016