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Regulation of cell-non-autonomous proteostasis in metazoans

Cells have developed robust adaptation mechanisms to survive environmental conditions that challenge the integrity of their proteome and ensure cellular viability. These are stress signalling pathways that integrate extracellular signals with the ability to detect and efficiently respond to protein-...

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Detalles Bibliográficos
Autores principales: O'Brien, Daniel, van Oosten-Hawle, Patricija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Limited 2016
Materias:
10
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065704/
https://www.ncbi.nlm.nih.gov/pubmed/27744329
http://dx.doi.org/10.1042/EBC20160006
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author O'Brien, Daniel
van Oosten-Hawle, Patricija
author_facet O'Brien, Daniel
van Oosten-Hawle, Patricija
author_sort O'Brien, Daniel
collection PubMed
description Cells have developed robust adaptation mechanisms to survive environmental conditions that challenge the integrity of their proteome and ensure cellular viability. These are stress signalling pathways that integrate extracellular signals with the ability to detect and efficiently respond to protein-folding perturbations within the cell. Within the context of an organism, the cell-autonomous effects of these signalling mechanisms are superimposed by cell-non-autonomous stress signalling pathways that allow co-ordination of stress responses across tissues. These transcellular stress signalling pathways orchestrate and maintain the cellular proteome at an organismal level. This article focuses on mechanisms in both invertebrate and vertebrate organisms that activate stress responses in a cell-non-autonomous manner. We discuss emerging insights and provide specific examples on how components of the cell-non-autonomous proteostasis network are used in cancer and protein-folding diseases to drive disease progression across tissues.
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spelling pubmed-50657042016-10-26 Regulation of cell-non-autonomous proteostasis in metazoans O'Brien, Daniel van Oosten-Hawle, Patricija Essays Biochem 10 Cells have developed robust adaptation mechanisms to survive environmental conditions that challenge the integrity of their proteome and ensure cellular viability. These are stress signalling pathways that integrate extracellular signals with the ability to detect and efficiently respond to protein-folding perturbations within the cell. Within the context of an organism, the cell-autonomous effects of these signalling mechanisms are superimposed by cell-non-autonomous stress signalling pathways that allow co-ordination of stress responses across tissues. These transcellular stress signalling pathways orchestrate and maintain the cellular proteome at an organismal level. This article focuses on mechanisms in both invertebrate and vertebrate organisms that activate stress responses in a cell-non-autonomous manner. We discuss emerging insights and provide specific examples on how components of the cell-non-autonomous proteostasis network are used in cancer and protein-folding diseases to drive disease progression across tissues. Portland Press Limited 2016-10-15 2016-10-15 /pmc/articles/PMC5065704/ /pubmed/27744329 http://dx.doi.org/10.1042/EBC20160006 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle 10
O'Brien, Daniel
van Oosten-Hawle, Patricija
Regulation of cell-non-autonomous proteostasis in metazoans
title Regulation of cell-non-autonomous proteostasis in metazoans
title_full Regulation of cell-non-autonomous proteostasis in metazoans
title_fullStr Regulation of cell-non-autonomous proteostasis in metazoans
title_full_unstemmed Regulation of cell-non-autonomous proteostasis in metazoans
title_short Regulation of cell-non-autonomous proteostasis in metazoans
title_sort regulation of cell-non-autonomous proteostasis in metazoans
topic 10
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065704/
https://www.ncbi.nlm.nih.gov/pubmed/27744329
http://dx.doi.org/10.1042/EBC20160006
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