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Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms
INTRODUCTION AND HYPOTHESIS: Epidemiological studies demonstrated that patients suffering from overactive bladder often present with different mental problems, amongst which depression is the most frequently observed. The main goal of our study was to check if the repeated administration of corticos...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer London
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065892/ https://www.ncbi.nlm.nih.gov/pubmed/27142032 http://dx.doi.org/10.1007/s00192-016-3027-3 |
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author | Wróbel, Andrzej Serefko, Anna Poleszak, Ewa Rechberger, Tomasz |
author_facet | Wróbel, Andrzej Serefko, Anna Poleszak, Ewa Rechberger, Tomasz |
author_sort | Wróbel, Andrzej |
collection | PubMed |
description | INTRODUCTION AND HYPOTHESIS: Epidemiological studies demonstrated that patients suffering from overactive bladder often present with different mental problems, amongst which depression is the most frequently observed. The main goal of our study was to check if the repeated administration of corticosterone (CORT) is able to evoke the depressive-like behaviour and detrusor overactivity (DO) symptoms in rats. Moreover, we investigated whether the acute administration of common antidepressants (imipramine, 30 mg/kg, and fluoxetine, 15 mg/kg), antimuscarinic (oxybutynin chloride, 0.5 mg/kg) or CRF(1) (SN 003, 1 mg/kg) antagonists has an impact on the cystometric parameters, behaviour in the Porsolt test, and overall locomotor activity of animals exposed to CORT. METHODS: The experiments were carried out on female Wistar rats. All applied surgical and histopathology procedures, cystometric investigations, locomotor activity and forced swim measurements have been fully described in the published literature. RESULTS: Fourteen-day administration of CORT may induce both depressive and DO symptoms in rats, which are reversed by the inhibition of CRF(1) receptors. CONCLUSIONS: It seems that the CRF(1) receptor could be an interesting target for overactive bladder pharmacotherapy, particularly in patients with co-existing depression. |
format | Online Article Text |
id | pubmed-5065892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer London |
record_format | MEDLINE/PubMed |
spelling | pubmed-50658922016-10-28 Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms Wróbel, Andrzej Serefko, Anna Poleszak, Ewa Rechberger, Tomasz Int Urogynecol J Original Article INTRODUCTION AND HYPOTHESIS: Epidemiological studies demonstrated that patients suffering from overactive bladder often present with different mental problems, amongst which depression is the most frequently observed. The main goal of our study was to check if the repeated administration of corticosterone (CORT) is able to evoke the depressive-like behaviour and detrusor overactivity (DO) symptoms in rats. Moreover, we investigated whether the acute administration of common antidepressants (imipramine, 30 mg/kg, and fluoxetine, 15 mg/kg), antimuscarinic (oxybutynin chloride, 0.5 mg/kg) or CRF(1) (SN 003, 1 mg/kg) antagonists has an impact on the cystometric parameters, behaviour in the Porsolt test, and overall locomotor activity of animals exposed to CORT. METHODS: The experiments were carried out on female Wistar rats. All applied surgical and histopathology procedures, cystometric investigations, locomotor activity and forced swim measurements have been fully described in the published literature. RESULTS: Fourteen-day administration of CORT may induce both depressive and DO symptoms in rats, which are reversed by the inhibition of CRF(1) receptors. CONCLUSIONS: It seems that the CRF(1) receptor could be an interesting target for overactive bladder pharmacotherapy, particularly in patients with co-existing depression. Springer London 2016-05-03 2016 /pmc/articles/PMC5065892/ /pubmed/27142032 http://dx.doi.org/10.1007/s00192-016-3027-3 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Wróbel, Andrzej Serefko, Anna Poleszak, Ewa Rechberger, Tomasz Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms |
title | Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms |
title_full | Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms |
title_fullStr | Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms |
title_full_unstemmed | Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms |
title_short | Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms |
title_sort | fourteen-day administration of corticosterone may induce detrusor overactivity symptoms |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065892/ https://www.ncbi.nlm.nih.gov/pubmed/27142032 http://dx.doi.org/10.1007/s00192-016-3027-3 |
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