Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis

INTRODUCTION: Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD). Tamoxifen has been generally well-tolerated, even without randomized controlled trials. CASE PRESENTATION: Herein, we report a case of a patient undergoing 12 years of PD who de...

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Autores principales: Li Tsai, Jun, Ju Wu, Ming, Hsu Chen, Cheng, Feng Tsai, Shang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065917/
https://www.ncbi.nlm.nih.gov/pubmed/27781116
http://dx.doi.org/10.5812/ircmj.30913
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author Li Tsai, Jun
Ju Wu, Ming
Hsu Chen, Cheng
Feng Tsai, Shang
author_facet Li Tsai, Jun
Ju Wu, Ming
Hsu Chen, Cheng
Feng Tsai, Shang
author_sort Li Tsai, Jun
collection PubMed
description INTRODUCTION: Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD). Tamoxifen has been generally well-tolerated, even without randomized controlled trials. CASE PRESENTATION: Herein, we report a case of a patient undergoing 12 years of PD who developed EPS and calciphylaxis simultaneously. We also provide a comprehensive discussion about the association between EPS and calciphylaxis. Moreover, although tamoxifen is used in EPS due to its inhibition of fibroblast-transforming growth factor beta (TGFβ) production, it may worsen the calciphylaxis due to a hypercoagulable state. CONCLUSIONS: We suggest avoiding the use of tamoxifen for EPS in patients with superimposed calciphylaxis.
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spelling pubmed-50659172016-10-25 Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis Li Tsai, Jun Ju Wu, Ming Hsu Chen, Cheng Feng Tsai, Shang Iran Red Crescent Med J Case Report INTRODUCTION: Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD). Tamoxifen has been generally well-tolerated, even without randomized controlled trials. CASE PRESENTATION: Herein, we report a case of a patient undergoing 12 years of PD who developed EPS and calciphylaxis simultaneously. We also provide a comprehensive discussion about the association between EPS and calciphylaxis. Moreover, although tamoxifen is used in EPS due to its inhibition of fibroblast-transforming growth factor beta (TGFβ) production, it may worsen the calciphylaxis due to a hypercoagulable state. CONCLUSIONS: We suggest avoiding the use of tamoxifen for EPS in patients with superimposed calciphylaxis. Kowsar 2016-06-15 /pmc/articles/PMC5065917/ /pubmed/27781116 http://dx.doi.org/10.5812/ircmj.30913 Text en Copyright © 2016, Iranian Red Crescent Medical Journal http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Case Report
Li Tsai, Jun
Ju Wu, Ming
Hsu Chen, Cheng
Feng Tsai, Shang
Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis
title Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis
title_full Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis
title_fullStr Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis
title_full_unstemmed Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis
title_short Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With Calciphylaxis
title_sort case report of a patient undergoing peritoneal dialysis with encapsulating peritoneal sclerosis superimposed with calciphylaxis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065917/
https://www.ncbi.nlm.nih.gov/pubmed/27781116
http://dx.doi.org/10.5812/ircmj.30913
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