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Multiple Sclerosis Patients Valuing Their Own Health Status: Valuation and Psychometric Properties of the 15D

An ongoing debate on decision and cost-utility analyses is whether to use preferences of general public or patients. The aim of this study was to replicate the valuation procedure of the multi-attribute utility generic measure, 15D, using a sample of multiple sclerosis (MS) patients and to assess it...

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Autores principales: Dagklis, Ioannis E., Aletras, Vasilis H., Tsantaki, Efthymia, Orologas, Anastasios, Niakas, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066103/
https://www.ncbi.nlm.nih.gov/pubmed/27761225
http://dx.doi.org/10.4081/ni.2016.6416
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author Dagklis, Ioannis E.
Aletras, Vasilis H.
Tsantaki, Efthymia
Orologas, Anastasios
Niakas, Dimitrios
author_facet Dagklis, Ioannis E.
Aletras, Vasilis H.
Tsantaki, Efthymia
Orologas, Anastasios
Niakas, Dimitrios
author_sort Dagklis, Ioannis E.
collection PubMed
description An ongoing debate on decision and cost-utility analyses is whether to use preferences of general public or patients. The aim of this study was to replicate the valuation procedure of the multi-attribute utility generic measure, 15D, using a sample of multiple sclerosis (MS) patients and to assess its psychometric properties. Consecutive outpatient MS patients were recruited from two MS centers in Greece. The three-stage valuation procedure was applied and, with the use of elicited preference weights, an MS patients’ algorithm was developed. The original Finnish value set derived from healthy individuals was also used to calculate scores and a comparison between the two algorithms was made. A total of 64 MS patients were evaluated. The 15D scores obtained with the MS patients’ valuation algorithm were higher than the original one. The derived utilities differed significantly with respect to age, depressive symptoms, Expanded Disability Status Scale score and clinical form. MS patients indicated as most important domains mobility, mental functioning and vitality. Cronbach’s alpha was estimated 0.876 and correlations between relevant dimensions of the instruments were moderate to high. The 15D was generally feasible and reliable in patients with MS and the valuation system yielded acceptable psychometric properties.
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spelling pubmed-50661032016-10-19 Multiple Sclerosis Patients Valuing Their Own Health Status: Valuation and Psychometric Properties of the 15D Dagklis, Ioannis E. Aletras, Vasilis H. Tsantaki, Efthymia Orologas, Anastasios Niakas, Dimitrios Neurol Int Article An ongoing debate on decision and cost-utility analyses is whether to use preferences of general public or patients. The aim of this study was to replicate the valuation procedure of the multi-attribute utility generic measure, 15D, using a sample of multiple sclerosis (MS) patients and to assess its psychometric properties. Consecutive outpatient MS patients were recruited from two MS centers in Greece. The three-stage valuation procedure was applied and, with the use of elicited preference weights, an MS patients’ algorithm was developed. The original Finnish value set derived from healthy individuals was also used to calculate scores and a comparison between the two algorithms was made. A total of 64 MS patients were evaluated. The 15D scores obtained with the MS patients’ valuation algorithm were higher than the original one. The derived utilities differed significantly with respect to age, depressive symptoms, Expanded Disability Status Scale score and clinical form. MS patients indicated as most important domains mobility, mental functioning and vitality. Cronbach’s alpha was estimated 0.876 and correlations between relevant dimensions of the instruments were moderate to high. The 15D was generally feasible and reliable in patients with MS and the valuation system yielded acceptable psychometric properties. PAGEPress Publications, Pavia, Italy 2016-09-30 /pmc/articles/PMC5066103/ /pubmed/27761225 http://dx.doi.org/10.4081/ni.2016.6416 Text en ©Copyright I.E. Dagklis et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Dagklis, Ioannis E.
Aletras, Vasilis H.
Tsantaki, Efthymia
Orologas, Anastasios
Niakas, Dimitrios
Multiple Sclerosis Patients Valuing Their Own Health Status: Valuation and Psychometric Properties of the 15D
title Multiple Sclerosis Patients Valuing Their Own Health Status: Valuation and Psychometric Properties of the 15D
title_full Multiple Sclerosis Patients Valuing Their Own Health Status: Valuation and Psychometric Properties of the 15D
title_fullStr Multiple Sclerosis Patients Valuing Their Own Health Status: Valuation and Psychometric Properties of the 15D
title_full_unstemmed Multiple Sclerosis Patients Valuing Their Own Health Status: Valuation and Psychometric Properties of the 15D
title_short Multiple Sclerosis Patients Valuing Their Own Health Status: Valuation and Psychometric Properties of the 15D
title_sort multiple sclerosis patients valuing their own health status: valuation and psychometric properties of the 15d
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066103/
https://www.ncbi.nlm.nih.gov/pubmed/27761225
http://dx.doi.org/10.4081/ni.2016.6416
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