The Basic Science of Bone Marrow Aspirate Concentrate in Chondral Injuries

There has been great interest in bone marrow aspirate concentrate (BMAC) as a cost effective method in delivering mesenchymal stem cells (MSCs) to aid in the repair and regeneration of cartilage defects. Alongside MSCs, BMAC contains a range of growth factors and cytokines to support cell growth fol...

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Detalles Bibliográficos
Autores principales: Holton, James, Imam, Mohamed, Ward, Jonathan, Snow, Martyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066111/
https://www.ncbi.nlm.nih.gov/pubmed/27761221
http://dx.doi.org/10.4081/or.2016.6659
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author Holton, James
Imam, Mohamed
Ward, Jonathan
Snow, Martyn
author_facet Holton, James
Imam, Mohamed
Ward, Jonathan
Snow, Martyn
author_sort Holton, James
collection PubMed
description There has been great interest in bone marrow aspirate concentrate (BMAC) as a cost effective method in delivering mesenchymal stem cells (MSCs) to aid in the repair and regeneration of cartilage defects. Alongside MSCs, BMAC contains a range of growth factors and cytokines to support cell growth following injury. However, there is paucity of information relating to the basic science underlying BMAC and its exact biological role in supporting the growth and regeneration of chondrocytes. The focus of this review is the basic science underlying BMAC in relation to chondral damage and regeneration.
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spelling pubmed-50661112016-10-19 The Basic Science of Bone Marrow Aspirate Concentrate in Chondral Injuries Holton, James Imam, Mohamed Ward, Jonathan Snow, Martyn Orthop Rev (Pavia) Article There has been great interest in bone marrow aspirate concentrate (BMAC) as a cost effective method in delivering mesenchymal stem cells (MSCs) to aid in the repair and regeneration of cartilage defects. Alongside MSCs, BMAC contains a range of growth factors and cytokines to support cell growth following injury. However, there is paucity of information relating to the basic science underlying BMAC and its exact biological role in supporting the growth and regeneration of chondrocytes. The focus of this review is the basic science underlying BMAC in relation to chondral damage and regeneration. PAGEPress Publications, Pavia, Italy 2016-09-30 /pmc/articles/PMC5066111/ /pubmed/27761221 http://dx.doi.org/10.4081/or.2016.6659 Text en ©Copyright J. Holton et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Holton, James
Imam, Mohamed
Ward, Jonathan
Snow, Martyn
The Basic Science of Bone Marrow Aspirate Concentrate in Chondral Injuries
title The Basic Science of Bone Marrow Aspirate Concentrate in Chondral Injuries
title_full The Basic Science of Bone Marrow Aspirate Concentrate in Chondral Injuries
title_fullStr The Basic Science of Bone Marrow Aspirate Concentrate in Chondral Injuries
title_full_unstemmed The Basic Science of Bone Marrow Aspirate Concentrate in Chondral Injuries
title_short The Basic Science of Bone Marrow Aspirate Concentrate in Chondral Injuries
title_sort basic science of bone marrow aspirate concentrate in chondral injuries
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066111/
https://www.ncbi.nlm.nih.gov/pubmed/27761221
http://dx.doi.org/10.4081/or.2016.6659
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