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Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor
[Image: see text] The aspartic proteinase renin is an attractive target for the treatment of hypertension and cardiovascular/renal disease such as chronic kidney disease and heart failure. We introduced an S1′ site binder into the lead compound 1 guided by structure-based drug design (SBDD), and fur...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066151/ https://www.ncbi.nlm.nih.gov/pubmed/27774132 http://dx.doi.org/10.1021/acsmedchemlett.6b00251 |