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Disabled-2 is a negative immune regulator of lipopolysaccharide-stimulated Toll-like receptor 4 internalization and signaling

Toll-like receptor 4 (TLR4) plays a pivotal role in the host response to lipopolysaccharide (LPS), a major cell wall component of Gram-negative bacteria. Here, we elucidated whether the endocytic adaptor protein Disabled-2 (Dab2), which is abundantly expressed in macrophages, plays a role in LPS-sti...

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Detalles Bibliográficos
Autores principales:	Hung, Wei-Shan, Ling, Pin, Cheng, Ju-Chien, Chang, Shy-Shin, Tseng, Ching-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066213/ https://www.ncbi.nlm.nih.gov/pubmed/27748405 http://dx.doi.org/10.1038/srep35343

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