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Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China

B vitamins play an essential role in DNA synthesis and methylation, and may protect against oesophageal and gastric cancers. In this case-cohort study, subjects were enrolled from the General Population Nutrition Intervention Trial in Linxian, China. Subjects included 498 oesophageal squamous cell c...

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Autores principales: Ren, Jiansong, Murphy, Gwen, Fan, Jinhu, Dawsey, Sanford M., Taylor, Philip R., Selhub, Jacob, Qiao, Youlin, Abnet, Christian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066215/
https://www.ncbi.nlm.nih.gov/pubmed/27748414
http://dx.doi.org/10.1038/srep35281
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author Ren, Jiansong
Murphy, Gwen
Fan, Jinhu
Dawsey, Sanford M.
Taylor, Philip R.
Selhub, Jacob
Qiao, Youlin
Abnet, Christian C.
author_facet Ren, Jiansong
Murphy, Gwen
Fan, Jinhu
Dawsey, Sanford M.
Taylor, Philip R.
Selhub, Jacob
Qiao, Youlin
Abnet, Christian C.
author_sort Ren, Jiansong
collection PubMed
description B vitamins play an essential role in DNA synthesis and methylation, and may protect against oesophageal and gastric cancers. In this case-cohort study, subjects were enrolled from the General Population Nutrition Intervention Trial in Linxian, China. Subjects included 498 oesophageal squamous cell carcinomas (OSCCs), 255 gastric cardia adenocarcinomas (GCAs), and an age- and sex-matched sub-cohort of 947 individuals. Baseline serum riboflavin, pyridoxal phosphate (PLP), folate, vitamin B12, and flavin mononucleotide (FMN) were measured for all subjects. We estimated the associations with Cox proportional hazard models, with adjustment for potential confounders. Compared to those in the lowest quartile of serum riboflavin, those in the highest had a 44% lower risk of OSCC (HR: 0.56, 95% CI: 0.41 to 0.75). Serum vitamin B12 as a continuous variable was observed to be significantly inversely associated with OSCC (HR: 0.95, 95% CI: 0.89 to 1.01, P for score test = 0.041). Higher serum FMN levels were significantly associated with increased risk of OSCC (HR: 1.08, 95% CI: 1.01 to 1.16) and GCA (HR: 1.09, 95% CI: 1.00 to 1.20). Our study prompted that B vitamins have the potential role as chemopreventive agents for upper gastrointestinal cancers.
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spelling pubmed-50662152016-10-26 Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China Ren, Jiansong Murphy, Gwen Fan, Jinhu Dawsey, Sanford M. Taylor, Philip R. Selhub, Jacob Qiao, Youlin Abnet, Christian C. Sci Rep Article B vitamins play an essential role in DNA synthesis and methylation, and may protect against oesophageal and gastric cancers. In this case-cohort study, subjects were enrolled from the General Population Nutrition Intervention Trial in Linxian, China. Subjects included 498 oesophageal squamous cell carcinomas (OSCCs), 255 gastric cardia adenocarcinomas (GCAs), and an age- and sex-matched sub-cohort of 947 individuals. Baseline serum riboflavin, pyridoxal phosphate (PLP), folate, vitamin B12, and flavin mononucleotide (FMN) were measured for all subjects. We estimated the associations with Cox proportional hazard models, with adjustment for potential confounders. Compared to those in the lowest quartile of serum riboflavin, those in the highest had a 44% lower risk of OSCC (HR: 0.56, 95% CI: 0.41 to 0.75). Serum vitamin B12 as a continuous variable was observed to be significantly inversely associated with OSCC (HR: 0.95, 95% CI: 0.89 to 1.01, P for score test = 0.041). Higher serum FMN levels were significantly associated with increased risk of OSCC (HR: 1.08, 95% CI: 1.01 to 1.16) and GCA (HR: 1.09, 95% CI: 1.00 to 1.20). Our study prompted that B vitamins have the potential role as chemopreventive agents for upper gastrointestinal cancers. Nature Publishing Group 2016-10-17 /pmc/articles/PMC5066215/ /pubmed/27748414 http://dx.doi.org/10.1038/srep35281 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Ren, Jiansong
Murphy, Gwen
Fan, Jinhu
Dawsey, Sanford M.
Taylor, Philip R.
Selhub, Jacob
Qiao, Youlin
Abnet, Christian C.
Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China
title Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China
title_full Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China
title_fullStr Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China
title_full_unstemmed Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China
title_short Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China
title_sort prospective study of serum b vitamins levels and oesophageal and gastric cancers in china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066215/
https://www.ncbi.nlm.nih.gov/pubmed/27748414
http://dx.doi.org/10.1038/srep35281
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