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Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies

CD8(+) T-cells play a role in the pathogenesis of autoimmune diseases such as multiple sclerosis and type 1 diabetes. However, drugs that target the entire CD8(+) T-cell population are not desirable because the associated lack of specificity can lead to unwanted consequences, most notably an enhance...

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Detalles Bibliográficos
Autores principales:	Clement, Mathew, Pearson, James A., Gras, Stephanie, van den Berg, Hugo A., Lissina, Anya, Llewellyn-Lacey, Sian, Willis, Mark D., Dockree, Tamsin, McLaren, James E., Ekeruche-Makinde, Julia, Gostick, Emma, Robertson, Neil P., Rossjohn, Jamie, Burrows, Scott R., Price, David A., Wong, F. Susan, Peakman, Mark, Skowera, Ania, Wooldridge, Linda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066216/ https://www.ncbi.nlm.nih.gov/pubmed/27748447 http://dx.doi.org/10.1038/srep35332

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